概要
研究テーマ
- 骨・骨格筋代謝調節機構の解明と再生医療への応用
- 運動器などにおける味覚受容体の役割の解明
- 遺伝子発現制御機構の解明
所属構成員
| 氏名 |
古株 彰一郎 |
| 役職 |
教授 |
| 研究内容 |
- ・骨・骨格筋代謝とBMPシグナル
- ・病態生理における味覚受容体
- ・転写コファクターによる遺伝子発現調節
|
| 氏名 |
松原 琢磨 |
| 役職 |
助教 |
| 研究内容 |
- ・破骨細胞の骨吸収に必須の分子c-Srcの下流分子の同定
- ・骨形成に関与する新規分子の探索
- ・がんの浸潤転移と中間径フィラメント関連タンパク質
|
| 氏名 |
Addison William |
| 役職 |
助教 |
| 研究内容 |
- ・遺伝子転写制御機構
- ・エピジェネティクス
- ・間葉系幹細胞
|
担当授業科目
- 歯学概論II
- 生物学特論
- 基礎医学Ⅰ、基礎医学Ⅱ
- 口腔基礎医学Ⅰ、口腔基礎医学Ⅲ、口腔基礎医学Ⅳ
- 基礎生命科学実習I（歯学科・口腔保健学科合同）
- 分子生物学実習
- 口腔インプラント学
- 総合講義 II
- 最新生命科学（生化学）
- 基礎生命科学Ⅲ（口腔保健学科）
主な実績
- Addison WN, Hall KC, Kokabu S, Matsubara T, Fu MM, Gori F, Baron R: Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation. Mol Cell Biol. e00447-18, 2019.
- Ogawa M, Yaginuma T, Nakatomi C, Nakajima T, Tada-Shigeyama Y, Addison WN, Urata M, Matsubara M, Watanabe K, Matsuo K, Sato T, Honda H, Hikiji H, Watanabe S, Kokabu S: Transducin-like Enhancer of Split 3 regulates proliferation of melanoma cells via histone deacetylase activity. Oncotarget, 404-414, 2018.
- Matsubara T, Urata M, Nakajima T, Fukuzaki M, Masuda R, Yoshimoto Y, Addison WN, Nakatomi C, Morikawa K, Zhang M, Saeki K, Takahashi Y, Nakamichi A, Kokabu S: Geranylgeraniol-induced myogenic differentiation of C2C12 cells. In Vivo, 1427-1431, 2018.
- Matsubara T, Takakura N, Urata M, Muramatsu Y, Tsuboi M, Yasuda K, Addison WN, Zhang M, Matsuo K, Nakatomi C, Tada-Shigeyama Y, Kaneuji T, Nakamichi A, Kokabu S: Geranylgeraniol induces PPARγ expression and enhances the biological effects of a PPARγ agonist in adipocyte lineage cells. In Vivo, 1339-1344, 2018.
- Kokabu S, Rosen V: BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling. FEBS Open Bio, 2017.
- Matsubara T, Kokabu S, Nakatomi C, Kinbara M, Maeda T, Yoshizawa M, Yasuda H, Takano-Yamamoto T, Baron R, Jimi E: The actin-binding protein PPP1r18 regulates maturation, actin organization, and bone resorption activity of osteoclasts. Mol Cell Biol, 38(4), e00425-17, 2017.
- Matsubara T, Kinbara M, Maeda T, Yoshizawa M, Kokabu S, Takano-Yamamoto T: Regulation of osteoclast differentiation and actin ring formation by the cytolinker protein plectin, Biochem Biophys Res Commun, 489, 472-6, 2017.
- Kokabu S, Nakatomi C, Matsubara T, Ono Y, Addison WN, Lowery JW, Urata M, Hudnall AM, Hitomi S, Nakatomi M, Sato T, Osawa K, Yoda T, Rosen V, Jimi E: The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor. J Biol Chem, 292, 12885-94, 2017.
- Kokabu S, Lowery JW, Toyono T, Sato T, Yoda T: On the Emerging Role of the Taste Receptor Type 1 (T1R) Family of Nutrient-Sensors in the Musculoskeletal System. Molecules, 22, E469, 2017.
- Kokabu S, Lowery JW, Jimi E: Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells. Stem Cells International, article ID 3753581, 7, 2016.
